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A Brief Introduction About Frozen Tissue Samples

Frozen tissues have the advantage of being faster than FFPE. This procedure uses a cryostat to mount and fix samples. It is used in many surgeries involving the removal of tumors. The margins can be examined to determine if it has been removed completely. Although FFPE tissue is not suitable for molecular gene analysis, frozen samples can be used. Because FFPE tissue samples can affect molecular data, this is why. 

Frozen tissue samples can also be used in mass spectrometry and next-generation sequencing. They are also useful for western blotting of post-translational protein modifications and quantitative real-time polymerase chain reactions. 

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Frozen tissue samples are the best choice for DNA and RNA sequencing, especially when there are more than 50 pairs. In immunohistochemistry, frozen tissue samples are also useful as the proteins are still preserved in their native state.

FFPE tissues are used most often in immunohistochemistry, where tissue sections are mounted onto slides. The tissue is then immersed in an antibody solution to enable it to attach to structures and proteins. Staining can be used to identify the protein structures and locations in the sample. This is crucial for studies on diseases like cancer and Alzheimer's. 

FFPE tissues are crucial for the following areas: oncology and hematology. A biopsy taken from a patient is reviewed by hospital pathologists and archived for future reference. FFPE can be used to preserve tissues donated from patients or animal samples and then archive them for future studies. These archives, also known as biobanks, can be created in hospitals, universities, or companies serving the research community.

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